2 edition of Genetic toxicology and cancer risk assessment found in the catalog.
Genetic toxicology and cancer risk assessment
Includes bibliographical references and index.
|Statement||edited by Wai Nang Choy.|
|Contributions||Choy, Wai Nang, 1946-|
|LC Classifications||RC268.65 .G46 2001, RC268.65 .G46 2001|
|The Physical Object|
|Pagination||xiii, 390 p. :|
|Number of Pages||390|
|LC Control Number||2001042183|
Cancer risk prediction models, based on epidemiologic data, calculate an individual’s likelihood of developing cancer, identify an individual’s risk of carrying a genetic mutation for a specific cancer (eg, BRCA 1 or BRCA 2), or both. 8, 9 Newer risk models are beginning to incorporate genomic profiles and environmental exposures, 10 a Cited by: CiteScore: ℹ CiteScore: CiteScore measures the average citations received per document published in this title. CiteScore values are based on citation counts in a given year (e.g. ) to documents published in three previous calendar years (e.g. – 14), divided by the number of documents in these three previous years (e.g. – 14).
Cancer risk assessment can be divided into two major categories: assessment of familial or genetic risk and assessment of environmental factors that may be causally related to cancer. Evaluation of familial risk should include both maternal and paternal lineages, with specific attention to cancers that co-exist in known hereditary cancer by: 4. The fundamental goal of toxicological research is to provide a rational basis for recommending acceptably safe levels of human exposure to potentially harmful agents. Chemically induced cancer Cited by: 4.
Editorial Board, Mutation Research - Genetic Toxicology and Environmental Mutagenesis National Center for Toxicological Research, Jefferson, Arkansas, United States Dr. Mei’s research program is focused on utilizing appropriate in vivo and in vitro mutation assays and toxicogenomic techniques to provide key toxicological information for FDA. Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms.
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Comprised of contributions from prominent experts and risk assessors and including nearly references to facilitate further study, Genetic Toxicology and Cancer Risk Assessment; reviews contemporary human cancer genetics as related to the mutagenic nature of carcinogenesis ; calculates acceptable exposure levels based on a carcinogenic threshold dose for nongenotoxic carcinogens ; reveals the rationale and methodology of quantitative estimation of human cancer risks Cited by: This book comprehensively reviews the various roles of genetic toxicology in human cancer risk assessment conducted by United States and worldwide regulatory agencies-discussing hazard identification, dose-response relationships, exposure assessment, and current practices of risk characterization.
This chapter discusses the history of the development of the field of genetic toxicology, the use of genetic toxicology data in cancer and genetic risk assessments, the mechanisms underlying genetic toxicology assays, the assays that can be used for detecting genotoxic endpoints, the use of the same assays for better understanding mechanisms of mutagenesis, and new methods for the assessment of genetic alterations.
In this chapter, we will discuss the history of the development of the field of genetic toxicology, the cellular pathways that counteract DNA damage on a daily basis, the use of genetic toxicology data in cancer and genetic risk assessments, the mechanisms underlying genetic toxicology assays, the assays that can be used for detecting genotoxic endpoints, the use of.
In Vivo Genetic Toxicology: Application to Cancer Risk Assessment Michael J. Schlosser and Christopher S.
Farabaugh Genotoxicity studies conducted in animals are a key component in carcinogenicity risk assessment, offering advantages over in vitro methods by accounting for chemical/drug dispositional effects and intact homeostatic : Michael J.
Schlosser, Christopher S. Farabaugh. Genetic Toxicology and Cancer Risk Assessment Informa Healthcare, New York, NY, pages. ISBN Topics covered in this book include reviews of mechanisms of carcinogenesis, and the role of genetic toxicology in human cancer risk assessment.
Genetic toxicology assesses the effects of chemical and physical agents on both DNA and on the genetic processes of living cells. This chapter addresses the assays for qualitative and quantitative assessment of cellular changes induced by chemical and physical agents, the underlying molecular mechanisms for these changes, and how such information can be incorporated in risk assessments.
Genetic Toxicology Testing Guidelines and Regulations. Lutz Müller. Head Full Development Projects, Non‐Clinical Drug Safety, F. Hoffmann‐La Roche Ltd., Basel, Switzerland Genetic Toxicology, Preclinical Safety, Novartis Institutes for BioMedical Research, Basel, Switzerland Cancer Risk Assessment: Chemical Carcinogenesis, Hazard.
Identification of Individuals for Cancer Genetics Risk Assessment and Counseling. Individuals are considered to be candidates for cancer risk assessment if they have a personal and/or family history (on the maternal or paternal side) or clinical characteristics with features suggestive of hereditary features vary by type of cancer and specific hereditary syndrome.
ISBN: OCLC Number: Description: xiii, pages: illustrations ; 24 cm: Contents: Human cancer genetics --Genetic toxicity for predicting carcinogenicity --Genotoxic and nongenotoxic mechanisms of carcinogenesis --Structure-activity relationship (SAR) and its role in cancer risk assessment --Regulatory genetic toxicology tests --Complementary genetic.
Genetic Toxicology and Cancer Risk Assessment, Hardcover by Choy, Wai Nang (EDT), ISBNISBNBrand New, Free shipping in the US Scientists from a number of disciplines and contributors from regulatory agencies look at the role of genetic toxicology in the various phases of cancer risk assessment, with a particular concern to.
This work reviews the roles of genetic toxicology in cancer risk assessment conducted by regulatory agencies worldwide - discussing hazard identification, dose-response relationships, exposure assessment and practices of risk characterization.
Genetic Toxicology is a comprehensive book covering the historical perspective of genetic toxicology; basic mechanisms of mutations and chromosomal effects; health consequences of genetic damage, including cancer and inheritable mutations; properties of physical, chemical, and biological mutagens; risk assessment of human exposure to genotoxicants; and the current.
This book compiles, discusses, and presents cutting-edge research data and methodology in performing risk assessment of some major chemicals of concern in our cturer: Pan Stanford.
• The somatic mutation theory of cancer and the environmental determinants of cancer: oncogenes, the proteins of oncogenes, tumor suppressor genes and their mutations.
• Monoclonal origin of atherosclerotic plaques and the induction of atherosclerosis. • Genetic risk assessment: radiation equivalent chemical concept, molecular dosimetry.
The purpose of genetic risk assessment is to identify individuals with a greater than average genetic contribution to disease, who may benefit from additional screening and preventive interventions.
Using clues from the personal and family history, you can classify an individual as average (general population), increased (moderate), or high (strong) risk. Provides a complete understanding of how our bodies respond to toxicants, and the principles used to assess the health risks of specific exposure scenarios Toxicology and Risk Assessment: A Comprehensive Introduction, Second Edition reflects recent advances in science and technology, and provides the scientific background and methodological issues to enable.
A Practical Guide to Toxicology and Human Health Risk Assessment Laura Robinson Toxicology Consulting Ltd, Brighton, UK.
Wiley also publishes its books in a variety of electronic formats and by print‐on‐demand. Some content Genetic T oxicology Buy Genetic Toxicology and Cancer Risk Assessment by Wai Nang Choy from Waterstones today.
Click and Collect from your local Waterstones or get FREE UK delivery on orders over £Author: Wai Nang Choy.
The explored new biomarkers by the omic techniques will provide forceful genotoxicity assessment to reduce the cancer risk. a genetic risk to man. Genetic Toxicology for human health risk. Cancer Genetics Risk Assessment and Counseling (PDQ®) health professional. Genetics of Breast and Gynecologic Cancers (PDQ®) health professional.
Genetics of Colorectal Cancer (PDQ®) health professional. Genetics of Endocrine and Neuroendocrine Neoplasias (PDQ®) health professional. Genetics of Kidney Cancer (Renal Cell Cancer) (PDQ®).SMH Hereditary Cancer and Genetic Testing program: Sarasota Memorial Hospital’s Genetic Education and Counseling Program provides evaluation, risk assessment, genetic testing and post-test counseling for breast, ovarian, colon, pancreatic, prostate, melanoma and many other hereditary cancers.Use of Toxicogenomics in Risk Assessment (The National Academy of Sciences, ): Exposure Assessment: Toxicogenomics is used to identify genetic patterns linked to genetic exposure due to any chemicals or other mixtures.
Standardized methods for identifying these signatures will be needed.